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Pharmacology & Drug Comparisons

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Racemic vs. Enantiopure: A Clinical Comparison of Modafinil and Armodafinil for Sustained Cognitive Performance

Racemic vs. Enantiopure: A Clinical Comparison of Modafinil and Armodafinil for Sustained Cognitive Performance

Modafinil and armodafinil share a common pharmacological lineage, yet their structural and metabolic distinctions produce meaningfully different clinical profiles. This review examines onset kinetics, duration of action, dosing considerations, and real-world tolerability to help clinicians and informed patients determine which agent may be better suited to specific cognitive demands and work schedules.